Authorities said both victims died driving on icy, snow packed roads.
"This has been a deadly winter storm," said Governor Sam Brownback. "Unfortunately, we lost a second life overnight because of slick roads."
The storm brought heavy snow and whiteout conditions to the western, central and eastern parts of the state.
Wind gusts up to 35 mph are expected to remain with the storm throughout the day making driving extremely dangerous.
"We urge everyone to avoid travel and be extremely cautious if you must be on the roads," said Col. Ernest Garcia, superintendent of the Kansas Highway Patrol.
A state of emergency remains in effect for the entire state.