It happened on Highway 31 just five miles north of Clarksdale around 4:00 a.m.
Troopers say Nicole Browden, 30, of Maysville came around a corner at a high rate of speed, crossed the centerline and went off the road.
The car began sliding, became airborne then overturned.
The crash killed Browden and her husband 27-year-old Michael Browden.
Troopers say they were both wearing seat belts.